Ordering Recommendation

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer three 1 mL aliquots of serum to individual ARUP Standard Transport Tubes and freeze immediately. (Min: 1.0 mL/tube)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Non-frozen specimens.

Remarks
Stability

Refer to individual components.

Methodology

Immunoturbidimetry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Quantitative Turbidimetry

Performed

Wed, Fri, Sat

Reported

1-4 days

Reference Interval

Test Number
Components
Reference Interval
  C-1-Esterase Inhibitor 21-38 mg/dL
  C-1-Esterase Inhib. Functional 41% or greater
  Complement Component 4
Age
Reference Interval (mg/dL)
0-30 days 8-30
1 month 9-33
2 months 9-37
3 months 10-35
4 months 10-49
5 months 9-48
6 months 12-55
7-8 months 13-48
9-11 months 16-51
1 year 16-52
2-4 years 12-47
5-11 years 13-44
12-17 years 14-41
18 years and older 10-40

  Alternative Complement Pathway Activity 31 percent normal or greater

Interpretive Data




Component Interpretation
C1-Esterase Inhibitor Functional 68% or greater     Normal
41-67%      Indeterminate
40% or less      Abnormal

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86160 x2; 86161

Components

Component Test Code* Component Chart Name LOINC
0050140 C-1-Esterase Inhibitor 4477-6
0050141 C-1-Esterase Inhib. Functional 48494-9
0050155 Complement Component 4 4498-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • C1
  • C1 esterase inhibitor
  • C1 esterase inhibitor, functional
  • C1 inhibitor
  • C1-inh
  • C4
  • Complement Component 4
C-1-Esterase Inhibitor Panel